M. W. Heartlein: search on Z-Library

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1

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in vivo with Fractional Factorial and Definitive Screening Designs

Kauffman, Kevin John, Dorkin, Joseph Robert, Yang, Jung Hoon, Heartlein, Michael W, DeRosa, Frank, Mir, Faryal F, Fenton, Owen Shea, Anderson, Daniel G.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.59 MB

english, 2015

2

Intrathecal delivery of recombinant human iduronate-2-sulfatase (idursulfase-IT)

P. Calias, J. Pan, Y. Huang, M. Alessandrini, N. Liu, R.W. Pfeifer, T.L. Wright, B.R. Felice, J. Powell, N. Savioli, J. Lotterhand, M.W. Heartlein

Journal:

Molecular Genetics and Metabolism

Year:

2011

Language:

english

File:

PDF, 53 KB

english, 2011

3

Iodine-124 as a Label for Pharmacological PET Imaging

Belov, Vasily V., Bonab, Ali A., Fischman, Alan J., Heartlein, Michael, Calias, Pericles, Papisov, Mikhail I.

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 3.83 MB

english, 2011

4

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

Kaczmarek, James C., Patel, Asha K., Kauffman, Kevin J., Fenton, Owen S., Webber, Matthew J., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

5

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs

Fenton, Owen, Kauffman, Kevin, McClellan, Rebecca, Kaczmarek, James, Zeng, Manhao, Andresen, Jason, Rhym, Luke, Heartlein, Michael, DeRosa, Frank, Anderson, Daniel G.

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 2.98 MB

english, 2018

6

Optimization of a Degradable Polymer-Lipid Nanoparticle for Potent Systemic Delivery of mRNA to the Lung Endothelium and Immune Cells

Kaczmarek, James Cliff, Kauffman, Kevin J, Fenton, Owen S., Sadtler, Kaitlyn, Patel, Asha K, Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.48 MB

english, 2018

7

Mutagenicity of municipal water obtained from an agricultural area

M. W. Heartlein, D. M. Demarini, A. J. Katz, Dr. H. E. Brockman, J. C. Means, M. J. Plewa

Journal:

Environmental and Molecular Mutagenesis

Year:

1981

Language:

english

File:

PDF, 708 KB

english, 1981

8

Safety evaluation of chronic intrathecal administration of heparan N-sulfatase in juvenile cynomolgus monkeys

Pfeifer, Richard W., Felice, Brian R., Boyd, Robert B., Butt, Mark T., Ruiz, Juan A., Heartlein, Michael W., Calias, Pericles

Journal:

Drug Delivery and Translational Research

Year:

2012

Language:

english

File:

PDF, 793 KB

english, 2012

9

The induction of specific-locus mutations and sister-chromatid exchanges by 5-bromo- and 5-chloro-deoxyuridine

M.W. Heartlein, J.P. O'Neill, B.C. Pal, R.J. Preston

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1982

Language:

english

File:

PDF, 286 KB

english, 1982

10

SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU

M.W. Heartlein, J.P. O'Neill, R.J. Preston

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1983

Language:

english

File:

PDF, 342 KB

english, 1983

11

Sister-chromatid exchanges and gene mutations are induced by the replication of 5-bromo- and 5-chloro-deoxyuridine substituted DNA

J.P. O'Neill, M.W. Heartlein, R.J. Preston

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1983

Language:

english

File:

PDF, 700 KB

english, 1983

12

An explanation of interspecific differences in sensitivity to X-ray-induced chromosome aberrations and a consideration of dose-response curves

M.W. Heartlein, R.J. Preston

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1985

Language:

english

File:

PDF, 542 KB

english, 1985

13

The effect of 3-aminobenzamide on the frequency of X-ray- or neutron-induced chromosome aberrations in cycling or non-cycling human lymphocytes

M.W. Heartlein, R.J. Preston

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1985

Language:

english

File:

PDF, 473 KB

english, 1985

14

Disparate effects of 5-bromodeoxyuridine on sister-chromatid exchanges and chromosomal aberrations in Bloom syndrome fibroblasts

H. Tsuji, M.W. Heartlein, S.A. Latt

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1988

Language:

english

File:

PDF, 1.02 MB

english, 1988

15

Human Sulfatase 2 inhibitsin vivotumor growth of MDA-MB-231 human breast cancer xenografts

Sarah M Peterson, Andrea Iskenderian, Lynette Cook, Alla Romashko, Kristen Tobin, Michael Jones, Angela Norton, Alicia Gómez-Yafal, Michael W Heartlein, Michael F Concino, Lucy Liaw, Paolo GV Martini

Journal:

Year:

2010

Language:

english

File:

PDF, 11.18 MB

english, 2010

16

5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity

.W. Heartlein, H. Tsuji, S.A. Latt

Journal:

Experimental Cell Research

Year:

1987

Language:

english

File:

PDF, 1.60 MB

english, 1987

17

Breakage of the human Y-chromosome short arm between two blocks of tandemly repeated DNA sequences

Müller, Ulrich, Lalande, Marc, Donlon, Timothy A., Heartlein, Michael W.

Journal:

Year:

1989

Language:

english

File:

PDF, 930 KB

english, 1989

18

Safety Evaluation of Chronic Intrathecal Administration of Idursulfase-IT in Cynomolgus Monkeys

Felice, B. R., Wright, T. L., Boyd, R. B., Butt, M. T., Pfeifer, R. W., Pan, J., Ruiz, J. A., Heartlein, M. W., Calias, P.

Journal:

Toxicologic Pathology

Year:

2011

Language:

english

File:

PDF, 1.30 MB

english, 2011

19

Amplified inverted duplications within and adjacent to heterologous selectable DNAS

Heartlein, M.W., Latt, S.A.

Journal:

Nucleic Acids Research

Year:

1989

Language:

english

File:

PDF, 2.91 MB

english, 1989

20

In vitro characterization of an acetylcholine receptor–transferrin fusion protein for the treatment of myasthenia gravis

Keefe, Dennis, Parng, Chuenlei, Lundberg, Dianna, Ray, Satyajit, Martineau-Bosco, Jennifer, Leng, Charan, Tzartos, Socrates, Powell, Jan, Concino, Michael, Heartlein, Michael, Lamsa, Justin, Josiah, S

Journal:

Year:

2010

Language:

english

File:

PDF, 403 KB

english, 2010

21

Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA delivery in vivo

Dong, Yizhou, Dorkin, J. Robert, Wang, Weiheng, Chang, Philip H, Webber, Matthew J, Tang, Benjamin C, Yang, Junghoon, Abutbul-Ionita, Inbal, Danino, Dganit, DeRosa, Frank, Heartlein, Michael, Langer,

Journal:

Year:

2016

Language:

english

File:

PDF, 1.26 MB

english, 2016

22

Long-Term Production and Delivery of Human Growth Hormone In vivo

Michael W. Heartlein, Victoria A. Roman, Ji-Lei Jiang, Joan W. Sellers, Antoinette M. Zuliani, Douglas A. Treco and Richard F. Selden

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.20 MB

english, 1994

23

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Fenton, Owen S., Kauffman, Kevin J., McClellan, Rebecca L., Appel, Eric A., Dorkin, J. Robert, Tibbitt, Mark W., Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.

Journal:

Advanced Materials

Year:

2016

Language:

english

File:

PDF, 1.53 MB

english, 2016

24

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system

DeRosa, F, Guild, B, Karve, S, Smith, L, Love, K, Dorkin, J R, Kauffman, K J, Zhang, J, Yahalom, B, Anderson, D G, Heartlein, M W

Journal:

Year:

2016

Language:

english

File:

PDF, 2.82 MB

english, 2016

25

Long-term production and delivery of human growth hormone in vivo.

Heartlein, M. W., Roman, V. A., Jiang, J. L., Sellers, J. W., Zuliani, A. M., Treco, D. A., Selden, R. F.

Journal:

Proceedings of the National Academy of Sciences

Year:

1994

Language:

english

File:

PDF, 1.17 MB

english, 1994

26

Chromosome instability associated with human alphoid DNA transfected into the Chinese hamster genome.

Heartlein, M W, Knoll, J H, Latt, S A

Journal:

Molecular and Cellular Biology

Year:

1988

Language:

english

File:

PDF, 1.83 MB

english, 1988

27

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

Kauffman, Kevin J., Mir, Faryal F., Jhunjhunwala, Siddharth, Kaczmarek, James C., Hurtado, Juan E., Yang, Jung H., Webber, Matthew J., Kowalski, Piotr S., Heartlein, Michael W., DeRosa, Frank, Anderso

Journal:

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

28

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

Kaczmarek, James C., Patel, Asha K., Kauffman, Kevin J., Fenton, Owen S., Webber, Matthew J., Heartlein, Michael W., DeRosa, Frank, Anderson, Daniel G.

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

29

WS09.1 Development of a CFTR mRNA therapy capable of treating lung disease in all CFTR patients

Smith, L., Karve, S., De Rosa, F., Kaza, N., Shei, R.-J., Stanford, D., Askew, K., Heartlein, M., Rowe, S., Mccauley, T.

Journal:

Journal of Cystic Fibrosis

Year:

2018

Language:

english

File:

PDF, 52 KB

english, 2018

30

Customizable Lipid Nanoparticle Materials for the Delivery of siRNAs and mRNAs

Fenton, Owen, Kauffman, Kevin, McClellan, Rebecca, Kaczmarek, James, Zeng, Manhao, Andresen, Jason, Rhym, Luke, Heartlein, Michael, DeRosa, Frank, Anderson, Daniel G.

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 2.98 MB

english, 2018

31

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Patel, Asha Kumari, Kaczmarek, James C., Bose, Suman, Kauffman, Kevin J., Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.

Journal:

Advanced Materials

Year:

2019

Language:

english

File:

PDF, 2.54 MB

english, 2019

32

Gene Delivery: Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium (Adv. Mater. 8/2019)

Patel, Asha Kumari, Kaczmarek, James C., Bose, Suman, Kauffman, Kevin J., Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.

Journal:

Advanced Materials

Year:

2019

File:

PDF, 2.14 MB

2019

33

Gene Delivery: Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium (Adv. Mater. 8/2019)

Patel, Asha Kumari, Kaczmarek, James C., Bose, Suman, Kauffman, Kevin J., Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert, Anderson, Daniel G.

Journal:

Advanced Materials

Year:

2019

File:

PDF, 2.14 MB

2019

34

mRNA Delivery for Therapeutic Anti-HER2 Antibody Expression In Vivo

Rybakova, Yulia, Kowalski, Piotr S., Huang, Yuxuan, Gonzalez, John T., Heartlein, Michael W., DeRosa, Frank, Delcassian, Derfogail, Anderson, Daniel G.

Journal:

Molecular Therapy

Year:

2019

Language:

english

File:

PDF, 436 KB

english, 2019